1981/09/11 by James E. Rothman · 3 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Cellular transport and secretion #Pancreatic function and diabetes #Endoplasmic Reticulum Stress and Disease
paper · doi:10.1126/science.7268428
openalex publication_date 1981/09/11 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/23
The Golgi apparatus consists of distinct cis and trans compartments that may act sequentially to refine the protein export of the endoplasmic reticulum by removing escaped endoplasmic reticulum proteins. Refinement may be a multistage process akin to fractional distillation; the stack of cisternae comprising the cis Golgi may be the plates in this distillation tower. The trans Golgi, consisting of the last one or two cisternae, may be the receiver that collects from the cis Golgi only its most refined fraction for later distribution to specific locations throughout the cell.