2004/08/26 by Marianne Fyhn, Sturla Molden, Menno P. Witter +2 · 2 citations
Neuroscience · #Memory and Neural Mechanisms #Neuroscience and Neuropharmacology Research #Stress Responses and Cortisol
paper · doi:10.1126/science.1099901
openalex publication_date 2004/08/26 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/04
As the interface between hippocampus and neocortex, the entorhinal cortex is likely to play a pivotal role in memory. To determine how information is represented in this area, we measured spatial modulation of neural activity in layers of medial entorhinal cortex projecting to the hippocampus. Close to the postrhinal-entorhinal border, entorhinal neurons had stable and discrete multipeaked place fields, predicting the rat's location as accurately as place cells in the hippocampus. Precise positional modulation was not observed more ventromedially in the entorhinal cortex or upstream in the postrhinal cortex, suggesting that sensory input is transformed into durable allocentric spatial representations internally in the dorsocaudal medial entorhinal cortex.