2003/07/01 by Joanna Masel, Aviv Bergman · 6 citations
Biochemistry, Genetics and Molecular Biology · #Fungal and yeast genetics research #Microbial Metabolic Engineering and Bioproduction #Prion Diseases and Protein Misfolding
paper · doi:10.1111/j.0014-3820.2003.tb00358.x
openalex publication_date 2003/07/01 · openalex created_date 2016/06/24 · openalex updated_date 2026/08/01
Saccharomyces cerevisiae's ability to form the prion [PSI+] may increase the rate of evolvability, defined as the rate of appearance of heritable and potentially adaptive phenotypic variants. The increase in evolvability occurs when the appearance of the prion causes read-through translation and reveals hidden variation in untranslated regions. Eventually the portion of the phenotypic variation that is adaptive loses its dependence on the revealing mechanism. The mechanism is reversible, so the restoration of normal translation termination conceals the revealed deleterious variation, leaving the yeast without a permanent handicap. Given that the ability to form [PSI+] is known to be fixed and conserved in yeast, we construct a mathematical model to calculate whether this ability is more likely to have become fixed due to chance alone or due to its evolvability characteristics. We find that evolvability is a more likely explanation, as long as environmental change makes partial read-through of stop codons adaptive at a frequency of at least once every million years.