Allosteric Mechanisms of Signal Transduction

2005/06/02 by Jean‐Pierre Changeux, Stuart J. Edelstein · 5 citations
Biochemistry, Genetics and Molecular Biology · Computer Science · #Receptor Mechanisms and Signaling #Nicotinic Acetylcholine Receptors Study #Computational Drug Discovery Methods

paper · doi:10.1126/science.1108595

openalex publication_date 2005/06/02 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31

Abstract

Forty years ago, a simple model of allosteric mechanisms (indirect interactions between distinct sites), used initially to explain feedback-inhibited enzymes, was presented by Monod, Wyman, and Changeux. We review the MWC theory and its applications for the understanding of signal transduction in biology, and also identify remaining issues that deserve theoretical and experimental substantiation.

Citations

• T and R states in the crystals of bacterial L–lactate dehydrogenase reveal the mechanism for allosteric control
• Mechanisms of cooperativity and allosteric regulation in proteins

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