New consensus nomenclature for mammalian keratins
2006/07/10 by Jürgen Schweizer, Jürgen Schweizer, Paul E. Bowden +12 · 27 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Skin and Cellular Biology Research #Nail Diseases and Treatments #Dermatological and Skeletal Disorders
paper · pdf · doi:10.1083/jcb.200603161
Abstract
Keratins are intermediate filament-forming proteins that provide mechanical support and fulfill a variety of additional functions in epithelial cells. In 1982, a nomenclature was devised to name the keratin proteins that were known at that point. The systematic sequencing of the human genome in recent years uncovered the existence of several novel keratin genes and their encoded proteins. Their naming could not be adequately handled in the context of the original system. We propose a new consensus nomenclature for keratin genes and proteins that relies upon and extends the 1982 system and adheres to the guidelines issued by the Human and Mouse Genome Nomenclature Committees. This revised nomenclature accommodates functional genes and pseudogenes, and although designed specifically for the full complement of human keratins, it offers the flexibility needed to incorporate additional keratins from other mammalian species.
Cited by
- Keratin: Structure, mechanical properties, occurrence in biological organisms, and efforts at bioinspiration
- The human keratins: biology and pathology
- Therapeutic siRNAs for dominant genetic skin disorders including pachyonychia congenita. [europepmc]
- Toward unraveling the complexity of simple epithelial keratins in human disease. [europepmc]
- The Streptococcus pneumoniae adhesin PsrP binds to Keratin 10 on lung cells. [europepmc]
- Keratins regulate protein biosynthesis through localization of GLUT1 and -3 upstream of AMP kinase and Raptor. [europepmc]
- Keratins in health and cancer: more than mere epithelial cell markers. [europepmc]
- Keratin gene mutations in disorders of human skin and its appendages. [europepmc]
- Cytoskeleton in motion: the dynamics of keratin intermediate filaments in epithelia. [europepmc]
- Defining keratin protein function in skin epithelia: epidermolysis bullosa simplex and its aftermath. [europepmc]
- Keratins mediate localization of hemidesmosomes and repress cell motility. [europepmc]
- The expanding significance of keratin intermediate filaments in normal and diseased epithelia. [europepmc]
- Networking galore: intermediate filaments and cell migration. [europepmc]
- Dynamic evolution of the alpha (α) and beta (β) keratins has accompanied integument diversification and the adaptation of birds into novel lifestyles. [europepmc]
- A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity. [europepmc]
- Keratins: Biomarkers and modulators of apoptotic and necrotic cell death in the liver. [europepmc]
- Types I and II Keratin Intermediate Filaments. [europepmc]
- Keratin 6, 16 and 17-Critical Barrier Alarmin Molecules in Skin Wounds and Psoriasis. [europepmc]
- Keratin - Based materials for biomedical applications. [europepmc]
- The epithelial-mesenchymal transition and the cytoskeleton in bioengineered systems. [europepmc]
- Anatomical structures, cell types and biomarkers of the Human Reference Atlas. [europepmc]
- Vimentin and cytokeratin: Good alone, bad together. [europepmc]
- Update of the keratin gene family: evolution, tissue-specific expression patterns, and relevance to clinical disorders. [europepmc]
- Novel Diagnostic Biomarkers in Colorectal Cancer. [europepmc]
- MicroRNA-485-5p targets keratin 17 to regulate oral cancer stemness and chemoresistance via the integrin/FAK/Src/ERK/β-catenin pathway. [europepmc]
- Type 2 Inflammation Contributes to Skin Barrier Dysfunction in Atopic Dermatitis. [europepmc]
- Effect of the Rho-Kinase/ROCK Signaling Pathway on Cytoskeleton Components. [europepmc]
Related