Thermodynamic uncertainty relation for biomolecular processes

2015/02/28 by Andre C. Barato, Udo Seifert · 10 citations
Physics and Astronomy · #cond-mat.stat-mech #physics.bio-ph

paper · pdf · doi:10.1103/physrevlett.114.158101

published as Phys. Rev. Lett. 114, 158101, 2015 · 5+6 pages, 3 figures

arxiv created 2015/04/30 · arxiv updated 2015/05/01

Abstract

Biomolecular systems like molecular motors or pumps, transcription and translation machinery, and other enzymatic reactions can be described as Markov processes on a suitable network. We show quite generally that in a steady state the dispersion of observables like the number of consumed/produced molecules or the number of steps of a motor is constrained by the thermodynamic cost of generating it. An uncertainty ε requires at least a cost of 2k_BT/ε² independent of the time required to generate the output.

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