2007/03/16 by Doru Constantin, Guillaume Brotons, Ansgar Jarre +2 · 35 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Immunology and Microbiology · Pharmacology, Toxicology and Pharmaceutics · Physics and Astronomy · #Advancements in Transdermal Drug Delivery #Alamethicin #Antimicrobial Peptides and Activities #Chemical physics #Chemistry #Crystallography #Lipid Membrane Structure and Behavior #Lipid bilayer #Membrane #Optics #Physics #RADIUS #Scattering #Structure factor #cond-mat.soft
paper · pdf · doi:10.1529/biophysj.106.101204
published in Biophysical Journal 92(11), 3978-3987 (Elsevier BV)
openalex publication_date 2007/03/16 · arxiv created 2015/04/11 · arxiv updated 2015/04/14 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/05
We have investigated the x-ray scattering signal of highly aligned multilayers of the zwitterionic lipid 1,2-dimyristoyl-sn-glycero-3-phosphatidylcholine containing pores formed by the antimicrobial peptide alamethicin as a function of the peptide/lipid ratio. We are able to obtain information on the structure factor of the pore fluid, which then yields the interaction potential between pores in the plane of the bilayers. Aside from a hard core with a radius corresponding to the geometric radius of the pore, we find a repulsive lipid-mediated interaction with a range of ≃ 30 Å and a contact value of 2.4 kBT. This result is in qualitative agreement with recent theoretical models.