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Understanding FOXP3: Progress Towards Achieving Transplantation Tolerance

2007/08/22 by Elaine Long, Kathryn J. Wood · 1 citation
Immunology and Microbiology · Biochemistry, Genetics and Molecular Biology · #Immune Cell Function and Interaction #T-cell and B-cell Immunology #Diabetes and associated disorders

paper · doi:10.1097/01.tp.0000275424.52998.ad

openalex publication_date 2007/08/22 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

Abstract

Regulatory T cells (Treg) suppress immune responses, making them an exciting therapeutic target for achieving operational transplant tolerance. Recent observations have identified forkhead box P3 (FOXP3) as a master gene required for the development and function of Treg. Improving our understanding of FOXP3 may facilitate methods for identifying and generating Treg.

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