1963/01/01 by Sukumar Rajauria, Christopher Axline, Claudia Gottstein +2
Engineering · Materials Science · Mathematics · Physics and Astronomy · #Algorithm #Binary number #Cell sorting #Civil and Geotechnical Engineering Research #Composite material #Composite number #Epistemology #Fluorescence #Materials science #Mathematics #Matrix (chemical analysis) #Micro and Nano Robotics #Microfluidic and Bio-sensing Technologies #Microfluidics #Nanoscopic scale #Particle (ecology) #Philosophy #Physics #Pickering emulsions and particle stabilization #Piezoelectricity #Resistive touchscreen #Sorting #Theoretical physics #cond-mat.soft #physics.ins-det
paper · pdf · doi:10.1021/nl503783p
published in OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) 15(1), 469-75 (Office of Scientific and Technical Information)
openalex publication_date 1963/01/01 · arxiv created 2014/12/05 · arxiv updated 2015/02/16 · openalex created_date 2016/06/24 · openalex updated_date 2026/06/24
The size- and fluorescence-based sorting of micro- and nanoscale particles suspended in fluid presents a significant and important challenge for both sample analysis and for manufacturing of nanoparticle-based products. Here, we demonstrate a disposable microfluidic particle sorter that enables high-throughput, on-demand counting and binary sorting of submicron particles and cells using either fluorescence or an electrically based determination of particle size. Size-based sorting uses a resistive pulse sensor integrated on-chip, whereas fluorescence-based discrimination is achieved using on-the-fly optical image capture and analysis. Following detection and analysis, the individual particles are deflected using a pair of piezoelectric actuators, directing the particles into one of two desired output channels; the main flow goes into a third waste channel. The integrated system can achieve sorting fidelities of better than 98%, and the mechanism can successfully count and actuate, on demand, more than 60,000 particles/min.