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Hallucinogenic N-Methylated Indolealkylamines in the Cerebrospinal Fluid of Psychiatric and Control Populations

1978/02/01 by Lionel Corbett, Samuel T. Christian, R. D. Morin +2 · 2 citations
Psychology · Neuroscience · #Psychedelics and Drug Studies #Tryptophan and brain disorders #Neurotransmitter Receptor Influence on Behavior

paper · doi:10.1192/bjp.132.2.139

openalex publication_date 1978/02/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/06/11

Abstract

The incidence and quantities of dimethyltryptamine and O-methylbufotenine were studied in the cerebrospinal fluid of patients suffering acute schizophrenic illnesses and in surgical and neurological control groups. Some schizophrenic patients have higher levels of both amines than do controls, though the differences in distribution did not reach statistical significance in the sample studied. The gas-chromatographic technique used is sensitive at the low picogram level.

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