Indole(ethyl)amine N -Methyltransferase in the Brain

1969/08/01 by M.R.A. Morgan, Arnold J. Mandell · 7 citations
Biochemistry, Genetics and Molecular Biology · #Amino Acid Enzymes and Metabolism #Epigenetics and DNA Methylation #Cancer, Hypoxia, and Metabolism

paper · doi:10.1126/science.165.3892.492

openalex publication_date 1969/08/01 · openalex created_date 2016/06/24 · openalex updated_date 2026/07/23

Abstract

An enzyme which N-methylates various indole(ethyl)amine substrates was isolated from brain, separated from the pituitary and the pineal glands. It appeared localized in the supernatant and synaptosomal areas after discontinuous sucrose-gradient ultracentrifugation. This is the first demonstration of the enzyme in brain.

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• ENZYMATIC N‐METHYLATION OF INDOLEAMINES BY MAMMALIAN BRAIN: FACT OR ARTEFACT?
• Indole(ethyl)amine N-Methyltransferase in Human Brain
• A Review of Recent Studies of the Biosynthesis and Excretion of Hallucinogens Formed by Methylation of Neurotransmitters or Related Substances
• Indoleamine-N-methyl transferase in human lung
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• Dimethyltryptamine [wikipedia]