1986/07/01 by Kazuhiko Yanai, Tatsuo Ido, Kiichi Ishiwata +6 · 3 citations
Biochemistry, Genetics and Molecular Biology · Medicine · Neuroscience · Psychology · #Aging, Health, and Disability #Neurotransmitter Receptor Influence on Behavior #Nicotinic Acetylcholine Receptors Study #Psychedelics and Drug Studies
paper · doi:10.1007/bf00276707
openalex publication_date 2007/01/01 · openalex created_date 2016/06/24 · openalex updated_date 2026/06/11
The endogenous hallucinogen, N,N-dimethyltryptamine (DMT), was labeled with carbon-11 and its regional distribution in rat brain studied. [11C]DMT showed higher accumulation in the cerebral cortex, caudate putamen, and amygdaloid nuclei. Studies of the subcellular distribution of [11C]DMT revealed the specific localization in the fractions enriched with serotonin receptors only when a very low dose was injected into rats. The proportions of the radioactivity in receptor-rich fractions were greatly enhanced by pretreatment with the monoamine oxidase inhibitor, pargyline. Specific binding of [11C]DMT to serotonin receptors in dog brain was demonstrated by a positron emission tomographic study in which 5-methoxy-N,N-dimethyltryptamine caused approximately 20% displacement of the radioligand from the receptors.