2006/01/01 by Stephanie J. Webb, Thomas Geoghegan, Russell A. Prough +1 · 3 citations
Medicine · #Hormonal and reproductive studies #Hormonal Regulation and Hypertension #Cholesterol and Lipid Metabolism
paper · doi:10.1080/03602530600569877
openalex publication_date 2006/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/15
Dehydroepiandrosterone has been thought to have physiological functions other than as an androgen precursor. The previous studies performed have demonstrated a number of biological effects in rodents, such as amelioration of disease in diabetic, chemical carcinogenesis, and obesity models. To date, activation of the peroxisome proliferators activated receptor alpha, pregnane X receptor, and estrogen receptor by DHEA and its metabolites have been demonstrated. Several membrane-associated receptors have also been elucidated leading to additional mechanisms by which DHEA may exert its biological effects. This review will provide an overview of the receptor multiplicity involved in the biological activity of this sterol.