Is serotonin an upper or a downer? The evolution of the serotonergic system and its role in depression and the antidepressant response

2015/01/24 by Paul W. Andrews, Aadil Bharwani, Kyuwon R. Lee +2 · 2 citations
Neuroscience · #Neural dynamics and brain function #Neurotransmitter Receptor Influence on Behavior #Tryptophan and brain disorders

paper · doi:10.1016/j.neubiorev.2015.01.018

openalex publication_date 2015/01/24 · crossref created 2015/01/24 · crossref issued 2015/04/01 · crossref published 2015/04/01 · crossref published-print 2015/04/01 · crossref deposited 2025/05/17 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01 · crossref indexed 2026/08/01

Citations

• Towards a glutamate hypothesis of depression
• Serotonin and Depression: A Disconnect between the Advertisements and the Scientific Literature
• Antidepressant Drug Effects and Depression Severity
• Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects
• The Myth of Reserpine-Induced Depression: Role in the Historical Development of the Monoamine Hypothesis
• The Expensive-Tissue Hypothesis: The Brain and the Digestive System in Human and Primate Evolution
• Strain differences in the neurochemical response to chronic restraint stress in the rat: Relevance to depression
• Loss of Antidepressant Efficacy During Maintenance Therapy
• Changing Food Preference as a Function of Mood
• About Sleep's Role in Memory
• Resting-State Brain Activity in Schizophrenia and Major Depression: A Quantitative Meta-Analysis
• Initial Severity and Antidepressant Benefits: A Meta-Analysis of Data Submitted to the Food and Drug Administration

Cited by

• Serotonin and depression
• Major depressive disorder [wikipedia]