Regulated adhesion as a driving force of gastrulation movements

2008/10/24 by Matthias Hammerschmidt, Doris Wedlich · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #Cellular Mechanics and Interactions #Cell Adhesion Molecules Research #Wnt/β-catenin signaling in development and cancer

paper · doi:10.1242/dev.015701

openalex publication_date 2008/10/24 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/15

Abstract

Recent data have reinforced the fundamental role of regulated cell adhesion as a force that drives morphogenesis during gastrulation. As we discuss, cell adhesion is required for all modes of gastrulation movements in all organisms. It can even be instructive in nature, but it must be tightly and dynamically regulated. The picture that emerges from the recent findings that we review here is that different modes of gastrulation movements use the same principles of adhesion regulation, while adhesion molecules themselves coordinate the intra- and extracellular changes required for directed cell locomotion.

Citations

• Cell surface mechanics and the control of cell shape, tissue patterns and morphogenesis
• Convergence and extension at gastrulation require a myosin IIB-dependent cortical actin network
• Cell interaction and its role in mesoderm cell migration during Xenopus gastrulation
• Directed movements and selective adhesion of embryonic amphibian cells

Cited by

• Developmental biology [wikipedia]

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