2011/12/27 by David Kimelman, Benjamin L. Martin · 1 citation
Biochemistry, Genetics and Molecular Biology · #Anatomy #Biology #Blastoderm #Body plan #Cell biology #Developmental Biology and Gene Regulation #Developmental biology #Drosophila (subgenus) #Drosophila embryogenesis #Embryo #Embryogenesis #Embryonic stem cell #Gastrulation #Gene #Genetics #Hippo pathway signaling and YAP/TAZ #Neurulation #Vertebrate #Wnt/β-catenin signaling in development and cancer #Zebrafish
paper · doi:10.1002/wdev.25
openalex publication_date 2011/12/27 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/03
Abstract The anterior–posterior (AP) axis is the most ancient of the embryonic axes and exists in most metazoans. Different animals use a wide variety of mechanisms to create this axis in the early embryo. In this study, we focus on three animals, including two insects ( Drosophila and Tribolium ) and a vertebrate (zebrafish) to examine different strategies used to form the AP axis. While Drosophila forms the entire axis within a syncytial blastoderm using transcription factors as morphogens, zebrafish uses signaling factors in a cellularized embryo, progressively forming the AP axis over the course of a day. Tribolium uses an intermediate strategy that has commonalities with both Drosophila and zebrafish. We discuss the specific molecular mechanisms used to create the AP axis and identify conserved features. WIREs Dev Biol 2012, 1:253–266. doi: 10.1002/wdev.25 This article is categorized under: Signaling Pathways > Global Signaling Mechanisms Early Embryonic Development > Gastrulation and Neurulation Early Embryonic Development > Development to the Basic Body Plan Comparative Development and Evolution > Body Plan Evolution