ACOG Practice Bulletin No. 77: Screening for Fetal Chromosomal Abnormalities

2007/01/01 · 6 citations
Medicine · #Prenatal Screening and Diagnostics

paper · doi:10.1097/00006250-200701000-00054

openalex publication_date 2007/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/09

Abstract

In the last decade, numerous markers and strategies for Down syndrome screening have been developed. Algorithms that combine ultrasound and serum markers in the first and second trimesters have been evaluated. Furthermore, the practice of using age cutoffs to determine whether women should be offered screening or invasive diagnostic testing has been challenged. The purpose of this document is to 1) present and evaluate the best available evidence for the use of ultrasonographic and serum markers for selected aneuploidy screening in pregnancy and 2) offer practical recommendations for implementing Down syndrome screening in practice.

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• Prenatal screening for trisomy 21: recent advances and guidelines
• Ethical considerations in first-trimester Down syndrome risk assessment
• Health Supervision for Children With Down Syndrome
• Prenatal diagnosis of Down syndrome: a systematic review of termination rates (1995–2011)
• Medical Update for Children With Down Syndrome for the Pediatrician and Family Practitioner
• Down syndrome [wikipedia]