2008/01/01 by Shirley Hodgson · 52 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #BRCA gene mutations in cancer #Biology #Cancer #Cancer research #Carcinogen #DNA Repair Mechanisms #DNA repair #Gene #Genetic factors in colorectal cancer #Genetics #Inheritance (genetic algorithm) #Mutation #Suppressor
paper · pdf · doi:10.1631/jzus.b073001
published in Journal of Zhejiang University SCIENCE B 9(1), 1-4 (Springer Science+Business Media)
openalex publication_date 2008/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31
A small proportion of many cancers are due to inherited mutations in genes, which result in a high risk to the individual of developing specific cancers. There are several classes of genes that may be involved: tumour suppressor genes, oncogenes, genes encoding proteins involved in DNA repair and cell cycle control, and genes involved in stimulating the angiogenic pathway. Alterations in susceptibility to cancer may also be due to variations in genes involved in carcinogen metabolism. This review discusses examples of some of these genes and the associated clinical conditions caused by the inheritance of mutations in such genes.