2010/06/24 by Qing‐Xi Yue, Xuan Liu, De‐an Guo · 1 citation
Medicine · Biochemistry, Genetics and Molecular Biology · #Cancer Treatment and Pharmacology #Cancer therapeutics and mechanisms #Microbial Natural Products and Biosynthesis
paper · pdf · doi:10.1055/s-0030-1250073
openalex publication_date 2010/06/24 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/04
Natural products, especially microtubule-binding natural products, play important roles in the war against cancer. From the clinical use of vinblastine in 1961, paclitaxel in 1992, to ixabepilone in 2007, microtubule-binding natural products have continually contributed to the development of cancer therapy. The present review summarizes the development of representative microtubule-binding natural products including agents binding to the colchicine-binding site, the VINCA alkaloid-binding site, the taxane-binding site and other binding sites. Future directions for the development of new anticancer microtubule-binding natural products are discussed. Finding new formulations, new targets and new sources of microtubule-binding natural products may enable more members of this kind of agent to be introduced into the clinic for cancer therapy.