Body Surface Area–based Dosing of 5-Fluoruracil Results in Extensive Interindividual Variability in 5-Fluorouracil Exposure in Colorectal Cancer Patients on FOLFOX Regimens

2011/05/25 by Jennifer Saam, Gregory C. Critchfield, Stephanie A. Hamilton +5 · 52 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Biochemical and Molecular Research #Biology #Cancer #Chemotherapy #Colorectal Cancer Treatments and Studies #Colorectal cancer #DPYD #Dihydropyrimidine dehydrogenase #Dosing #FOLFOX #Fluorouracil #Gene #Genotype #Internal medicine #Medicine #Oncology #Oxaliplatin #Pancreatic and Hepatic Oncology Research #Pharmacogenetics #Pharmacology #Thymidylate synthase

paper · doi:10.1016/j.clcc.2011.03.015

published in Clinical Colorectal Cancer 10(3), 203-206 (Elsevier BV)

openalex publication_date 2011/05/25 · crossref created 2011/05/25 · crossref issued 2011/09/01 · crossref published 2011/09/01 · crossref published-print 2011/09/01 · openalex created_date 2025/10/10 · crossref deposited 2025/10/26 · crossref indexed 2025/12/04 · openalex updated_date 2026/06/26

Citations

• Individual Fluorouracil Dose Adjustment Based on Pharmacokinetic Follow-Up Compared With Conventional Dosage: Results of a Multicenter Randomized Trial of Patients With Metastatic Colorectal Cancer

Cited by

• Modeling the 5-Fluorouracil Area Under the Curve Versus Dose Relationship to Develop a Pharmacokinetic Dosing Algorithm for Colorectal Cancer Patients Receiving FOLFOX6
• Chemotherapy [wikipedia]