The shared epitope hypothesis. an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis

1987/11/01 by Peter K. Gregersen, Jack Silver, Robert Winchester +1 · 8 citations
Medicine · #Autoimmune and Inflammatory Disorders Research #Rheumatoid Arthritis Research and Therapies #Systemic Lupus Erythematosus Research

paper · doi:10.1002/art.1780301102

crossref issued 1987/11/01 · crossref published 1987/11/01 · crossref published-print 1987/11/01 · openalex publication_date 1987/11/01 · crossref published-online 2005/11/29 · crossref created 2007/02/14 · crossref deposited 2023/11/23 · openalex created_date 2025/10/10 · crossref indexed 2026/07/31 · openalex updated_date 2026/08/01

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• Recent advances in the genetics of rheumatoid arthritis
• Rheumatoid arthritis
• Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis
• Association of Rheumatoid Arthritis with HLA-DR1 and HLA-DR4 in Hungary
• A gene–environment interaction between smoking and shared epitope genes in HLA–DR provides a high risk of seropositive rheumatoid arthritis
• Extra-articular rheumatoid arthritis
• Periodontal disease and periodontal bacteria as triggers for rheumatoid arthritis
• Rheumatoid arthritis [wikipedia]