Interim Estimates of Vaccine Effectiveness of BNT162b2 and mRNA-1273 COVID-19 Vaccines in Preventing SARS-CoV-2 Infection Among Health Care Personnel, First Responders, and Other Essential and Frontline Workers — Eight U.S. Locations, December 2020–March 2021

2021/03/29 by Mark G. Thompson, Jefferey L. Burgess, Allison L. Naleway +41 · 4 citations
Medicine · Social Sciences · #SARS-CoV-2 and COVID-19 Research #Viral gastroenteritis research and epidemiology #Vaccine Coverage and Hesitancy

paper · pdf · doi:10.15585/mmwr.mm7013e3

openalex publication_date 2021/03/29 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31

Abstract

In contrast, among fully immunized (≥14 days after second dose) persons, 0.04 infections per 1,000 person-days were reported, and among partially immunized (≥14 days after first dose and before second dose) persons, 0.19 infections per 1,000 person-days were reported. Estimated mRNA vaccine effectiveness for prevention of infection, adjusted for study site, was 90% for full immunization and 80% for partial immunization. These findings indicate that authorized mRNA COVID-19 vaccines are effective for preventing SARS-CoV-2 infection, regardless of symptom status, among working-age adults in real-world conditions. COVID-19 vaccination is recommended for all eligible persons.

Citations

• Estimating the extent of asymptomatic COVID-19 and its potential for community transmission: Systematic review and meta-analysis
• Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine
• Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

Cited by

• Effectiveness of COVID-19 Vaccines in Preventing SARS-CoV-2 Infection Among Frontline Workers Before and During B.1.617.2 (Delta) Variant Predominance — Eight U.S. Locations, December 2020–August 2021
• A review of the safety and efficacy of current COVID-19 vaccines
• Lack of effects on female fertility and prenatal and postnatal offspring development in rats with BNT162b2, a mRNA-based COVID-19 vaccine
• COVID-19 vaccine [wikipedia]