2019/02/19 by Piotr S. Kowalski, Arnab Rudra, Lei Miao +1 · 2 citations
Biochemistry, Genetics and Molecular Biology · #RNA Interference and Gene Delivery #Advanced biosensing and bioanalysis techniques #Virus-based gene therapy research
paper · pdf · doi:10.1016/j.ymthe.2019.02.012
openalex publication_date 2019/02/19 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
mRNA has broad potential as a therapeutic. Current clinical efforts are focused on vaccination, protein replacement therapies, and treatment of genetic diseases. The clinical translation of mRNA therapeutics has been made possible through advances in the design of mRNA manufacturing and intracellular delivery methods. However, broad application of mRNA is still limited by the need for improved delivery systems. In this review, we discuss the challenges for clinical translation of mRNA-based therapeutics, with an emphasis on recent advances in biomaterials and delivery strategies, and we present an overview of the applications of mRNA-based delivery for protein therapy, gene editing, and vaccination.