Thermal analysis characterization of aortic tissues for cardiac valve bioprostheses

1999/09/15 by V. Samouillan, Jany Dandurand, J. Dandurand-Lods +12 · 125 citations
Engineering · Medicine · #Aortic valve #Biomedical engineering #Cardiac valve #Cardiology #Elasticity and Material Modeling #Heart valve #Internal medicine #Materials science #Medicine #Orthopaedic implants and arthroplasty #Tribology and Lubrication Engineering

paper · doi:10.1002/(sici)1097-4636(19990915)46:4<531::aid-jbm11>3.0.co;2-2

published in Journal of Biomedical Materials Research 46(4), 531-538 (Wiley)

openalex publication_date 1999/09/15 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/22

Abstract

Two multistep extractions were achieved on porcine aortic tissues to obtain acellular matrices used for cardiac bioprostheses. The evaluation of structural modifications and the possible damage of extracellular matrix fibrous proteins were investigated by means of thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). Protein-water interactions and degradation temperatures were determined by TGA. DSC was used to characterize protein thermal transitions (glass transition and denaturation), which provided information on the dynamic structure of the aortic tissue components. Sodium dodecyl sulfate (SDS) extraction had a destructuring effect, while Triton and cholate treatments did not affect the structural integrity of either elastin and collagen. A DSC comparison showed that SDS destabilizes the collagen triple helical domain and swells the elastin network.

Citations

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