Osteoarthritic changes in the biphasic mechanical properties of the chondrocyte pericellular matrix in articular cartilage

2004/06/07 by Leonidas G. Alexopoulos, Gregory M. Williams, Maureen L. Upton +2 · 27 citations
Medicine · Engineering · #Osteoarthritis Treatment and Mechanisms #Lower Extremity Biomechanics and Pathologies #Total Knee Arthroplasty Outcomes

paper · doi:10.1016/j.jbiomech.2004.04.012

Cited by

• Three‐dimensional morphology of the pericellular matrix of intervertebral disc cells in the rat
• Matrix Development in Self-Assembly of Articular Cartilage
• Zonal changes in the three-dimensional morphology of the chondron under compression: the relationship among cellular, pericellular, and extracellular deformation in articular cartilage. [europepmc]
• Differential expression of GADD45beta in normal and osteoarthritic cartilage: potential role in homeostasis of articular chondrocytes. [europepmc]
• Defining the roles of inflammatory and anabolic cytokines in cartilage metabolism. [europepmc]
• The dynamic mechanical environment of the chondrocyte: a biphasic finite element model of cell-matrix interactions under cyclic compressive loading. [europepmc]
• Developmental and osteoarthritic changes in Col6a1-knockout mice: biomechanics of type VI collagen in the cartilage pericellular matrix. [europepmc]
• Composition of the pericellular matrix modulates the deformation behaviour of chondrocytes in articular cartilage under static loading. [europepmc]
• Cartilage cell clusters. [europepmc]
• Biomechanical factors in osteoarthritis. [europepmc]
• Multiscale mechanics of articular cartilage: potentials and challenges of coupling musculoskeletal, joint, and microscale computational models. [europepmc]
• A biomechanical role for perlecan in the pericellular matrix of articular cartilage. [europepmc]
• Immunofluorescence-guided atomic force microscopy to measure the micromechanical properties of the pericellular matrix of porcine articular cartilage. [europepmc]
• Depth-dependent anisotropy of the micromechanical properties of the extracellular and pericellular matrices of articular cartilage evaluated via atomic force microscopy. [europepmc]
• Primary human chondrocyte extracellular matrix formation and phenotype maintenance using RGD-derivatized PEGDM hydrogels possessing a continuous Young's modulus gradient. [europepmc]
• Atomic force microscopy reveals regional variations in the micromechanical properties of the pericellular and extracellular matrices of the meniscus. [europepmc]
• Micromechanical mapping of early osteoarthritic changes in the pericellular matrix of human articular cartilage. [europepmc]
• Electrospun cartilage-derived matrix scaffolds for cartilage tissue engineering. [europepmc]
• The structure and function of the pericellular matrix of articular cartilage. [europepmc]
• Substrate Stiffness Controls Osteoblastic and Chondrocytic Differentiation of Mesenchymal Stem Cells without Exogenous Stimuli. [europepmc]
• Direct measurement of TRPV4 and PIEZO1 activity reveals multiple mechanotransduction pathways in chondrocytes. [europepmc]
• Influence of the pericellular and extracellular matrix structural properties on chondrocyte mechanics. [europepmc]
• Osteoarthritis as a disease of the cartilage pericellular matrix. [europepmc]
• Modulating Viscoelasticity, Stiffness, and Degradation of Synthetic Cellular Niches via Stoichiometric Tuning of Covalent versus Dynamic Noncovalent Cross-Linking. [europepmc]
• A dysfunctional TRPV4-GSK3β pathway prevents osteoarthritic chondrocytes from sensing changes in extracellular matrix viscoelasticity. [europepmc]
• Mechanical Cues: Bidirectional Reciprocity in the Extracellular Matrix Drives Mechano-Signalling in Articular Cartilage. [europepmc]
• Biomechanics of Chondrocytes and Chondrons in Healthy Conditions and Osteoarthritis: A Review of the Mechanical Characterisations at the Microscale. [europepmc]