2014/05/31 by Haleh Ebadi, Konstantin Klemm · 11 citations
Biochemistry, Genetics and Molecular Biology · Mathematics · Physics and Astronomy · #Bacterial Genetics and Biotechnology #Boolean function #Boolean network #Computer science #Discrete mathematics #Dynamical systems theory #Gene Regulatory Network Analysis #Mathematics #Microbial Metabolic Engineering and Bioproduction #Physics #Representation (politics) #Veto #cond-mat.dis-nn #q-bio.MN
paper · pdf · doi:10.1103/physreve.90.022815
published in Physical Review E 90(2), 022815 (American Physical Society) · 7 pages, 3 figures, 3 tables, v2: minor revision
openalex publication_date 2014/08/26 · arxiv created 2014/08/27 · arxiv updated 2014/09/05 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/05
Boolean networks are discrete dynamical systems for modeling regulation and signaling in living cells. We investigate a particular class of Boolean functions with inhibiting inputs exerting a veto (forced zero) on the output. We give analytical expressions for the sensitivity of these functions and provide evidence for their role in natural systems. In an intracellular signal transduction network [Helikar et al., Proc. Natl. Acad. Sci. USA 105, 1913 (2008)], the functions with veto are over-represented by a factor exceeding the over-representation of threshold functions and canalyzing functions in the same system. In Boolean networks for control of the yeast cell cycle [Li et al., Proc. Natl. Acad. Sci. USA 101, 4781 (2004); Davidich et al., PLoS ONE 3, e1672 (2008)], no or minimal changes to the wiring diagrams are necessary to formulate their dynamics in terms of the veto functions introduced here.