CO-Sensing Mechanisms

2004/09/01 by Gary P. Roberts, Hwan Youn, Robert L. Kerby · 3 citations
Biochemistry, Genetics and Molecular Biology · #Hemoglobin structure and function #Heme Oxygenase-1 and Carbon Monoxide #Porphyrin Metabolism and Disorders

paper · doi:10.1128/mmbr.68.3.453-473.2004

openalex publication_date 2004/09/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/15

Abstract

Carbon monoxide (CO) has long been known to have dramatic physiological effects on organisms ranging from bacteria to humans, but recently there have a number of suggestions that organisms might have specific sensors for CO. This article reviews the current evidence for a variety of proteins with demonstrated or potential CO-sensing ability. Particular emphasis is placed on the molecular description of CooA, a heme-containing CO sensor from Rhodospirillum rubrum, since its biological role as a CO sensor is clear and we have substantial insight into the basis of its sensing ability.

Citations

• Redox-operated genetic switches: the SoxR and OxyR transcription factors
• Transcription activation by catabolite activator protein (CAP)
• Soil microorganisms as controllers of atmospheric trace gases (H2, CO, CH4, OCS, N2O, and NO)

Cited by

• Gaseous O2, NO, and CO in Signal Transduction: Structure and Function Relationships of Heme-Based Gas Sensors and Heme-Redox Sensors
• Carbon monoxide, reactive oxygen signaling, and oxidative stress
• Carbon monoxide [wikipedia]