GRP75 mediates endoplasmic reticulum–mitochondria coupling during palmitate-induced pancreatic β-cell apoptosis

2021/10/29 by Shweta Tiwary, Arun Nandwani, Rukshar Khan +1 · 18 citations
Medicine · Biochemistry, Genetics and Molecular Biology · #Pancreatic function and diabetes #Endoplasmic Reticulum Stress and Disease #Mitochondrial Function and Pathology

paper · doi:10.1016/j.jbc.2021.101368

Abstract

levels and ROS generation, augment ER-mitochondria contact, and induce apoptosis in these cells. In vivo injection of palmitate induced hyperglycemia and hypertriglyceridemia, as well as impaired glucose and insulin tolerance in mice. These animals also exhibited elevated GRP75 levels accompanied by enhanced apoptosis within the pancreatic islets. Our findings suggest that GRP75 is critical in mediating palmitate-induced ER-mitochondrial interaction leading to apoptosis in pancreatic islet cells.

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