2010/06/08 by C. Chrubasik, Raymond L. Jacobson · 1 citation
Medicine · Computer Science · #Malaria Research and Control #Computational Drug Discovery Methods #Mosquito-borne diseases and control
paper · doi:10.1002/ptr.3133
openalex publication_date 2010/06/08 · openalex created_date 2025/10/10 · openalex updated_date 2026/05/21
Despite world-wide efforts in fighting malaria, this mosquito-borne infectious disease is a huge burden for the population, especially in tropical and subtropical areas. The WHO recommends artemisinin-based combination therapy for the treatment of uncomplicated Plasmodium falciparum malaria. However, artemisinin resistance cannot now be ignored. Factors affecting the development of artemisinin resistance include uncontrolled use of artemisinin-based combination therapy (ACT), mobile populations and migrants, artemisinin monotherapy, the use of subtherapeutic levels of artesiminin, substandard and counterfeit drugs, high treatment cost, and co-use of artemisinin derivates as prophylactic agents. Promising herbal alternatives are already in the pipeline, but the only long-term solution for eradicating malaria would be the development of a successful vaccination.