2016/08/11 by Jonny Karunia Fajar · 1 citation
Medicine · #Blood properties and coagulation
paper · pdf · doi:10.1016/j.ejmhg.2016.06.002
openalex publication_date 2016/08/11 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
There are many studies about the association of β fibrinogen gene G-455A polymorphism and the risk of coronary heart disease (CHD). However, the results of these studies are inconsistent. This study aimed to investigate the association of β fibrinogen gene G-455A polymorphism with the risk of CHD using meta analysis. This study was limited to the Asian population. Published studies from PubMed, Embase, and CNKI databases (up to December 20th, 2015) were searched for eligible publications. The following information was extracted from each study: (1) name of first author; (2) year of publication; (3) country of origin; (4) sample size of cases and controls, and (5) size of each allele. The combined odds ratios (ORs) and 95% confidence intervals (95% CIs) for the association between β fibrinogen gene G-455A polymorphism and the risk of CHD were assessed using random or fixed effect model. A comprehensive meta analysis (CMA) 2.0 was used to analyze the data. Nineteen studies (4011 cases/3673 controls) regarding the association of β fibrinogen gene G-455A polymorphism and the risk of CHD were included in this meta analysis. The results indicated that β fibrinogen gene G-455A polymorphism was associated with increased (A vs. G: OR 95% CI = 1.42 [1.19–1.70], p < 0.001; AA vs. GG + GA: OR 95% CI = 1.60 [1.13–2.26], p = 0.008; GA vs. GG + AA: OR 95% CI = 1.30 [1.07–1.58], p = 0.008) and decreased the risk of CHD (G vs. A: OR 95% CI = 0.70 [0.59–0.84], p < 0.001; GG vs. GA + AA: OR 95% CI = 0.68 [0.55–0.84], p < 0.001). In the Asian population, the β fibrinogen gene G-455A polymorphism was associated with the risk of CHD.