Diffusion-weighted imaging: As the first diagnostic clue to Creutzfeldt Jacob disease

2012/09/01 by Sunitha Palasamudram Kumaran, Kanchan Gupta, B. T. Pushpa +2 · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #Prion Diseases and Protein Misfolding #Infectious Encephalopathies and Encephalitis

paper · pdf · doi:10.4103/0976-3147.102645

openalex publication_date 2012/09/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/06/26

Abstract

We describe a case report where the diagnosis of sporadic Creutzfeldt-Jakob disease(CJD) was suspected by the magnetic resonance imaging (MRI) radiologist in a 75-year-old lady who presented with rapid cognitive decline. MRI revealed cortical T2 and FLAIR(fluid attenuation and inversion recovery) hyperintensities in bilateral fronto-parietal and temporo-occipital locations and showed significant restriction on diffusion-weighted images(DWI). In this case report, we discuss the role of MRI to suspect the diagnosis of CJD in appropriate clinical settings.

Cited by

• Creutzfeldt–Jakob disease [wikipedia]

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