Glucose Phosphotransferase System Modulates Pyruvate Metabolism, Bacterial Fitness, and Microbial Ecology in Oral Streptococci

2022/12/05 by Lin Zeng, Alejandro R. Walker, Robert A. Burne +1 · 23 citations
Biochemistry, Genetics and Molecular Biology · Dentistry · #Bacteria #Biochemistry #Biofilm #Bioinformatics #Biology #Carbohydrate metabolism #Enzyme #Genetics #Genomics and Phylogenetic Studies #Gut microbiota and health #Metabolism #Microbial ecology #Microbial metabolism #Microbiology #Microbiome #Oral Microbiome #Oral microbiology and periodontitis research #PEP group translocation #Phosphoenolpyruvate carboxykinase #Streptococcus #Streptococcus gordonii #Streptococcus sanguinis

paper · open access · doi:10.1128/jb.00352-22

published in Journal of Bacteriology 205(1), e0035222 (American Society for Microbiology)

openalex publication_date 2022/12/05 · openalex created_date 2025/10/10 · openalex updated_date 2026/06/24

Abstract

mutants engineered in three different oral streptococci displayed altered capacities for acid production and interspecies antagonism, highlighting the potential for targeting the glucose-PTS to modulate the pathogenicity of oral biofilms.

Citations

• CcpA Regulates Central Metabolism and Virulence Gene Expression in Streptococcus mutans
• Influence of BrpA on Critical Virulence Attributes ofStreptococcus mutans
• Essential Roles of the sppRA Fructose-Phosphate Phosphohydrolase Operon in Carbohydrate Metabolism and Virulence Expression by Streptococcus mutans
• The tragedy of the commons in microbial populations: insights from theoretical, comparative and experimental studies

Cited by

• A Transcriptional Analysis Showing the Effects of GH12 Combined with Fluoride for Suppressing the Acidogenicity of Streptococcus mutans Biofilms. [europepmc]
• Glycerol metabolism contributes to competition by oral streptococci through production of hydrogen peroxide. [europepmc]
• Systematic analysis of the glucose-PTS in Streptococcus sanguinis highlighted its importance in central metabolism and bacterial fitness. [europepmc]
• Genome-wide analysis of Enterococcus faecalis genes that facilitate interspecies competition with Lactobacillus crispatus . [europepmc]
• Fructose activates a stress response shared by methylglyoxal and hydrogen peroxide in Streptococcus mutans . [europepmc]
• The Abundance of Viroid-Like RNA Obelisk-S.s in Streptococcus sanguinis SK36 May Suffice for Evolutionary Persistence. [europepmc]
• Analysis of the diversity and function of the microbiota in infected root canals of type 2 diabetes mellitus with apical periodontitis. [europepmc]
• Characterization of Streptococcus mitis subsp. carlssonii isolated from human vagina: prevalence, phenotypic, and genomic insights. [europepmc]
• Pyruvate metabolism is involved in adaptability and cariogenicity of Streptococcus mutans . [europepmc]
• Rapid growth phenotype of carbapenem-resistant Enterobacter cloacae: growth fitness, stability, and mechanistic insights. [europepmc]
• A comparative study on arginine metabolism by oral streptococci revealed both divergence and heterogeneity in dependence on arginine and significance of ornithine and citrulline. [europepmc]

Related

• Essential Roles of the sppRA Fructose-Phosphate Phosphohydrolase Operon in Carbohydrate Metabolism and Virulence Expression by Streptococcus mutans
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• Oral Streptococci... Products of Their Environment
• Influence of BrpA on Critical Virulence Attributes ofStreptococcus mutans
• Identification of a conserved GNAT-family lysine acetyltransferase in Streptococcus gordonii involved in biofilm formation and oral colonization