Staphylococcus aureus osmoregulation: roles for choline, glycine betaine, proline, and taurine

1992/04/01 by J E Graham, James E. Graham, B J Wilkinson +1 · 26 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Aldose Reductase and Taurine #Amino acid #Bacteria #Betaine #Biochemistry #Biology #Cardiac Ischemia and Reperfusion #Choline #Ecology #Ectoine #Glycine #Nitric Oxide and Endothelin Effects #Osmoprotectant #Osmoregulation #Osmotic concentration #Osmotic shock #Proline #Salinity #Staphylococcus aureus #Taurine

paper · doi:10.1128/jb.174.8.2711-2716.1992

openalex publication_date 1992/04/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30

Abstract

Choline, glycine betaine, and L-proline enhanced the growth of Staphylococcus aureus at high osmolarity (i.e., they acted as osmoprotectants) on various liquid and solid defined media, while an osmoprotective effect of taurine was shown only for cells growing on high-NaCl solid medium that lacked other osmoprotectants. Potassium pool levels were high, and there was little difference in levels in cells grown at different osmolarities. Glycine betaine accumulated to high levels in osmotically stressed cells, and choline was converted to glycine betaine. Proline and taurine also accumulated in response to osmotic stress but to lower levels than glycine betaine.

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