Essential Roles of the <i>sppRA</i> Fructose-Phosphate Phosphohydrolase Operon in Carbohydrate Metabolism and Virulence Expression by <i>Streptococcus mutans</i>

2018/10/23 by Lin Zeng, Robert A. Burne · 13 citations
Medicine · Dentistry · Biochemistry, Genetics and Molecular Biology · #Streptococcal Infections and Treatments #Oral microbiology and periodontitis research #Infections and bacterial resistance

paper · pdf · doi:10.1128/jb.00586-18

Abstract

Streptococcus mutans is a major etiologic agent for dental caries, primarily due to its ability to form biofilms on the tooth surface and to convert carbohydrates into organic acids. We have discovered a two-gene operon in S. mutans that regulates fructose metabolism by controlling the levels of fructose-1-phosphate, a potential signaling compound that affects bacterial behaviors. With fructose becoming increasingly common and abundant in the human diet, we reveal the ways that fructose may alter bacterial development, stress tolerance, and microbial ecology in the oral cavity to promote oral diseases.

Citations

• Comprehensive Mutational Analysis of Sucrose-Metabolizing Pathways in Streptococcus mutans Reveals Novel Roles for the Sucrose Phosphotransferase System Permease
• CcpA Regulates Central Metabolism and Virulence Gene Expression in <i>Streptococcus mutans</i>

Cited by

• Glucose Phosphotransferase System Modulates Pyruvate Metabolism, Bacterial Fitness, and Microbial Ecology in Oral Streptococci
• The Structure of Dental Plaque Microbial Communities in the Transition from Health to Dental Caries and Periodontal Disease. [europepmc]
• Novel Probiotic Mechanisms of the Oral Bacterium Streptococcus sp. A12 as Explored with Functional Genomics. [europepmc]
• Molecular mechanisms controlling fructose-specific memory and catabolite repression in lactose metabolism by Streptococcus mutans. [europepmc]
• Subpopulation behaviors in lactose metabolism by Streptococcus mutans. [europepmc]
• A single system detects and protects the beneficial oral bacterium Streptococcus sp. A12 from a spectrum of antimicrobial peptides. [europepmc]
• Potential of Prebiotic D-Tagatose for Prevention of Oral Disease. [europepmc]
• [Research Updates: Cariogenic Mechanism of Streptococcus mutans ]. [europepmc]
• Glucose Phosphotransferase System Modulates Pyruvate Metabolism, Bacterial Fitness, and Microbial Ecology in Oral Streptococci. [europepmc]
• CcpA and CodY Regulate CRISPR-Cas System of Streptococcus mutans . [europepmc]
• Glycerol metabolism contributes to competition by oral streptococci through production of hydrogen peroxide. [europepmc]
• Fructose activates a stress response shared by methylglyoxal and hydrogen peroxide in Streptococcus mutans . [europepmc]
• A Streptococcus mutans retrospective: from oral pathogen to bacterial paradigm. [europepmc]

Related

• Comprehensive Mutational Analysis of Sucrose-Metabolizing Pathways in Streptococcus mutans Reveals Novel Roles for the Sucrose Phosphotransferase System Permease
• Glucose Phosphotransferase System Modulates Pyruvate Metabolism, Bacterial Fitness, and Microbial Ecology in Oral Streptococci
• Comparing the cariogenic species Streptococcus sobrinus and S. mutans on whole genome level
• CcpA Regulates Central Metabolism and Virulence Gene Expression in <i>Streptococcus mutans</i>
• Influence of BrpA on Critical Virulence Attributes of<i>Streptococcus mutans</i>