2024/01/19 by Yuyuan Cai, Xuehong Zhang · 4 citations
Biochemistry, Genetics and Molecular Biology · Engineering · #Bacterial biofilms and quorum sensing #Bacterial Genetics and Biotechnology #Biosensors and Analytical Detection
paper · doi:10.1128/jb.00430-23
ABSTRACT Quorum sensing (QS) is an elaborate regulatory mechanism associated with virulence and bacterial adaptation to the changing environment. QS is widespread in Proteobacteria and acts primarily through N -acylhomoserine lactone (AHL) signals. At the core of the AHL-driven QS systems are the AHL synthase gene ( luxI family) and its cognate transcriptional regulator gene ( luxR family). Several QS systems display one or more genes intervening between the luxI and luxR , in which gene arrangements are notably different due to the relative position and the transcriptional orientation between the essential luxI/R and the genes of location correlation. These adjacent genes may exert a regulatory impact on the primary QS genes or contribute toward an extension of QS regulatory control. In this review, we describe the organization of AHL-driven QS genes based on previous research and specific genome databases and provide new insights into these atypical QS gene arrangements.