2003/09/22 by David I. Bassett, Peter D. Currie · 2 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Muscle Physiology and Disorders #Cardiomyopathy and Myosin Studies #Congenital heart defects research
paper · pdf · doi:10.1093/hmg/ddg279
openalex publication_date 2003/09/22 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30
The muscular dystrophies and congenital myopathies are inherited diseases of the skeletal muscle, which lead to a loss of muscle function and are often fatal. While many of the loci involved are already known, these conditions remain incurable, and genetic models are being developed in an effort to understand the pathological mechanisms involved. Recently several papers have shown that the zebrafish, which is now widely used in developmental genetic studies, will provide a useful addition to our toolkit in this regard. Here we describe these studies, including a zebrafish model of what is potentially the novel pathological mechanism of muscle attachment failure in Duchenne and other muscular dystrophies.