Neutralization Escape by SARS-CoV-2 Omicron Subvariants BA.2.12.1, BA.4, and BA.5

2022/06/22 by Nicole P. Hachmann, Jessica Miller, Ai‐ris Y. Collier +8 · 2 citations
Medicine · Agricultural and Biological Sciences · #SARS-CoV-2 and COVID-19 Research #Animal Virus Infections Studies #COVID-19 Clinical Research Studies

paper · pdf · doi:10.1056/nejmc2206576

openalex publication_date 2022/06/22 · openalex created_date 2022/06/24 · openalex updated_date 2026/08/01

Abstract

To the Editor: In recent months, multiple lineages of the omicron (B.1.1.529) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have emerged, 1 with subvariants BA.1 and BA.2 showing substantial escape from neutralizing antibodies. 2-5 Subvariant BA.2.12.1 is now the dominant strain in the United States, and BA.4 and BA.5 are dominant in South Africa (Fig. Subvariants BA.4 and BA.5 have identical sequences of the spike protein.

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