2005/02/09 by Adrian Hill, Hiroki Teraoka, Warren Heideman +1 · 2 citations
Biochemistry, Genetics and Molecular Biology · Veterinary · #Zebrafish Biomedical Research Applications #Animal testing and alternatives #CRISPR and Genetic Engineering
paper · doi:10.1093/toxsci/kfi110
openalex publication_date 2005/02/09 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29
Zebrafish (Danio rerio) has been a prominent model vertebrate in a variety of biological disciplines. Substantial information gathered from developmental and genetic research, together with near-completion of the zebrafish genome project, has placed zebrafish in an attractive position for use as a toxicological model. Although still in its infancy, there is a clear potential for zebrafish to provide valuable new insights into chemical toxicity, drug discovery, and human disease using recent advances in forward and reverse genetic techniques coupled with large-scale, high-throughput screening. Here we present an overview of the rapidly increasing use of zebrafish in toxicology. Advantages of the zebrafish both in identifying endpoints of toxicity and in elucidating mechanisms of toxicity are highlighted.