PROMOTIF—A program to identify and analyze structural motifs in proteins

1996/02/01 by E. Gail Hutchinson, Janet M. Thornton · 4 citations
Biochemistry, Genetics and Molecular Biology · Materials Science · #Protein Structure and Dynamics #Enzyme Structure and Function #RNA and protein synthesis mechanisms

paper · doi:10.1002/pro.5560050204

openalex publication_date 1996/02/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/17

Abstract

We describe a suite of programs, PROMOTIF, that analyzes a protein coordinate file and provides details about the structural motifs in the protein. The program currently analyzes the following structural features: secondary structure; beta-and gamma-turns; helical geometry and interactions; beta-strands and beta-sheet topology; beta-bulges; beta-hairpins; beta-alpha-beta units and psi-loops; disulphide bridges; and main-chain hydrogen bonding patterns. PROMOTIF creates postscript files showing the examples of each type of motif in the protein, and a summary page. The program can also be used to compare motifs in a group of related structures, such as an ensemble of NMR structures.

Citations

• The protein data bank: A computer-based archival file for macromolecular structures
• Dictionary of protein secondary structure: Pattern recognition of hydrogen‐bonded and geometrical features
• The Anatomy and Taxonomy of Protein Structure

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• Structures of single‐layer β‐sheet proteins evolved from β‐hairpin repeats
• Beta sheet [wikipedia]