2010/01/01 by Marek Kochańczyk, Joanna Jaruszewicz-Błońska, Tomasz Lipniacki +3 · 1 citation
Biochemistry, Genetics and Molecular Biology · Engineering · Health Professions · Neuroscience · Physics and Astronomy · #Gene Regulatory Network Analysis #Infant Health and Development #Molecular Communication and Nanonetworks #Neuroscience of respiration and sleep #stochastic dynamics and bifurcation
paper · pdf · doi:10.1098/rsif.2013.0151
openalex publication_date 2010/01/01 · openalex created_date 2016/06/24 · openalex updated_date 2026/06/11
Transitions between steady states of a multi-stable stochastic system in the perfectly mixed chemical reactor are possible only because of stochastic switching. In realistic cellular conditions, where diffusion is limited, transitions between steady states can also follow from the propagation of travelling waves. Here, we study the interplay between the two modes of transition for a prototype bistable system of kinase-phosphatase interactions on the plasma membrane. Within microscopic kinetic Monte Carlo simulations on the hexagonal lattice, we observed that for finite diffusion the behaviour of the spatially extended system differs qualitatively from the behaviour of the same system in the well-mixed regime. Even when a small isolated subcompartment remains mostly inactive, the chemical travelling wave may propagate, leading to the activation of a larger compartment. The activating wave can be induced after a small subdomain is activated as a result of a stochastic fluctuation. Such a spontaneous onset of activity is radically more probable in subdomains characterized by slower diffusion. Our results show that a local immobilization of substrates can lead to the global activation of membrane proteins by the mechanism that involves stochastic fluctuations followed by the propagation of a semi-deterministic travelling wave.