2019/01/01 by Qian He, Xiaohua Chen, Tang Na Wu +2 · 1 citation
Psychology · Medicine · Neuroscience · #Sleep and related disorders #Dementia and Cognitive Impairment Research #Sleep and Wakefulness Research
paper · pdf · doi:10.3988/jcn.2019.15.1.9
openalex publication_date 2019/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/14
BACKGROUND AND PURPOSE: There is conflicting evidence in the literature on the association between benzodiazepines (BDZs) and the risk of dementia. This meta-analysis aimed to determine the relationship between the long-term usage of BDZs and the risk of dementia. METHODS: The PubMed and Embase databases were systematically searched for relevant publications up to September 2017. The literature search focused on observational studies that analyzed the relationship between the long-term use of BDZs and the risk of dementia. Pooled rate ratios (RRs) with 95% confidence interval (CI) were assessed using a random-effects model. The robustness of the results was checked by performing subgroup and sensitivity analyses. RESULTS: =0.016). CONCLUSIONS: This meta-analysis that pooled ten studies has shown that BDZ significantly increases the risk of dementia in the elderly population. The risk is higher in patients taking BDZ with a longer half-life (>20 hours) and for a longer duration (>3 years).