2018/05/01 by Tianze Cheng, D. Wallace, Benjamin Bixby Ponteri +1 · 1 citation
Neuroscience · Agricultural and Biological Sciences · #Neuroscience and Neuropharmacology Research #GABA and Rice Research #Neurotransmitter Receptor Influence on Behavior
paper · pdf · doi:10.2147/ndt.s164307
openalex publication_date 2018/05/01 · openalex created_date 2018/06/01 · openalex updated_date 2026/07/29
Abstract: Benzodiazepines are one of the most prescribed medications as first-line treatment of anxiety, insomnia, and epilepsy around the world. Over the past two decades, advances in the neuropharmacological understanding of gamma aminobutyric acid (GABA) A receptors revealed distinct contributions from each subtype and produced effects. Recent findings have highlighted the importance of α1 containing GABA A receptors in the mechanisms of addiction and tolerance in benzodiazepine treatments. This has shown promise in the development of tranquilizers with minimal side effects such as cognitive impairment, dependence, and tolerance. A valium-like drug without its side effects, as repeatedly demonstrated in animals, is achievable. Keywords: benzodiazepines, subtype, tolerance, dependence, anxiolytic, GABA A receptor