Protein Oxidation and Aging

1992/08/28 by Earl R. Stadtman · 6 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Advanced Glycation End Products research #Coenzyme Q10 studies and effects #Antioxidant Activity and Oxidative Stress

paper · doi:10.1126/science.1355616

openalex publication_date 1992/08/28 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/23

Abstract

A number of systems that generate oxygen free radicals catalyze the oxidative modification of proteins. Such modifications mark enzymes for degradation by cytosolic neutral alkaline proteases. Protein oxidation contributes to the pool of damaged enzymes, which increases in size during aging and in various pathological states. The age-related increase in amounts of oxidized protein may reflect the age-dependent accumulation of unrepaired DNA damage that, in a random manner, affects the concentrations or activities of numerous factors that govern the rates of protein oxidation and the degradation of oxidized protein.

Citations

• Aging: A Theory Based on Free Radical and Radiation Chemistry

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• Antioxidant [wikipedia]