Intracellular calcium dynamics permit a Purkinje neuron model to perform toggle and gain computations upon its inputs

2014/08/20 by Michael Forrest · 2 citations
Neuroscience · #Neural dynamics and brain function #Neuroscience and Neural Engineering #Photoreceptor and optogenetics research

paper · pdf · doi:10.3389/fncom.2014.00086

openalex publication_date 2014/08/20 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30

Abstract

Without synaptic input, Purkinje neurons can spontaneously fire in a repeating trimodal pattern that consists of tonic spiking, bursting and quiescence. Climbing fiber input (CF) switches Purkinje neurons out of the trimodal firing pattern and toggles them between a tonic firing and a quiescent state, while setting the gain of their response to Parallel Fiber (PF) input. The basis to this transition is unclear. We investigate it using a biophysical Purkinje cell model under conditions of CF and PF input. The model can replicate these toggle and gain functions, dependent upon a novel account of intracellular calcium dynamics that we hypothesize to be applicable in real Purkinje cells.

Citations

• The neural substrates of rapid-onset Dystonia-Parkinsonism
• The Sodium-Potassium Pump Controls the Intrinsic Firing of the Cerebellar Purkinje Neuron
• The NEURON Simulation Environment
• DENDRITIC COMPUTATION

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• Simulation of alcohol action upon a detailed Purkinje neuron model and a simpler surrogate model that runs >400 times faster
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