2010/03/24 by Evan L. Ardiel, Catharine H. Rankin · 1 citation
Biochemistry, Genetics and Molecular Biology · Neuroscience · Psychology · #Genetics, Aging, and Longevity in Model Organisms #Circadian rhythm and melatonin #Neuroendocrine regulation and behavior
paper · pdf · doi:10.1101/lm.960510
openalex publication_date 2010/03/24 · openalex created_date 2016/06/24 · openalex updated_date 2026/07/14
This article reviews the literature on learning and memory in the soil-dwelling nematode Caenorhabditis elegans. Paradigms include nonassociative learning, associative learning, and imprinting, as worms have been shown to habituate to mechanical and chemical stimuli, as well as learn the smells, tastes, temperatures, and oxygen levels that predict aversive chemicals or the presence or absence of food. In each case, the neural circuit underlying the behavior has been at least partially described, and forward and reverse genetics are being used to elucidate the underlying cellular and molecular mechanisms. Several genes have been identified with no known role other than mediating behavior plasticity.