2021/08/21 by Katharina Schimmel, Md Khadem Ali, Serena Y. Tan +5 · 1 citation
Medicine · #Arteriovenous malformation #Disease #Intensive care medicine #Medicine #Pathogenesis #Pathology #Radiology #Therapeutic approach #Vascular Anomalies and Treatments #Vascular Malformations Diagnosis and Treatment #Vascular Malformations and Hemangiomas
paper · pdf · doi:10.3390/ijms22169037
openalex publication_date 2021/08/21 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
Arteriovenous malformations are a vascular anomaly typically present at birth, characterized by an abnormal connection between an artery and a vein (bypassing the capillaries). These high flow lesions can vary in size and location. Therapeutic approaches are limited, and AVMs can cause significant morbidity and mortality. Here, we describe our current understanding of the pathogenesis of arteriovenous malformations based on preclinical and clinical findings. We discuss past and present accomplishments and challenges in the field and identify research gaps that need to be filled for the successful development of therapeutic strategies in the future.