2004/09/01 by Michel Bourin, Éric Dailly, Martine Hascoët · 3 citations
Medicine · Neuroscience · Psychology · #Alcoholism and Thiamine Deficiency #Anxiolytic #Benzodiazepine #Dopamine #Dopaminergic #Internal medicine #Medicine #Neurotransmitter Receptor Influence on Behavior #Obsessive-Compulsive Spectrum Disorders #Pharmacology #Receptor
paper · pdf · doi:10.1111/j.1527-3458.2004.tb00023.x
openalex publication_date 2004/09/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
Several studies have suggested that the antipsychotic compound, cyamemazine, possesses anxiolytic properties in humans. The original pharmacological profile of cyamemazine (D(2), 5-HT(2A), 5-HT(2C), and 5-HT(3) receptor antagonist), which was established by binding, microdialysis and behavioral studies, is consistent with these observations. In the light/dark exploration test, cyamemazine demonstrated anxiolytic-like activity by acute, but not chronic administration. By chronic administration, however, cyamemazine increased the time spent in the open arms of the elevated plus maze (EPM) test demonstrating anxiolytic-like activity. The discrepancy between the results obtained in these tests by acute and chronic administration, could be due to a combination of dopamine D(2) receptor antagonism with antagonism of the 5-HT(2C) and 5-HT(3) receptors. The action of cyamemazine on both the dopaminergic system and 5-HT(3) receptors could also explain the activity of cyamemazine in the management of alcohol withdrawal demonstrated in preclinical studies. This potential indication for cyamemazine and its activity in benzodiazepine withdrawal syndrome have recently been investigated in clinical trials and the results of these studies are presented in this review.