2002/05/31 by Guoqing Chen, David V. Goeddel · 6 citations
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · Medicine · #NF-κB Signaling Pathways #Immune Response and Inflammation #Cytokine Signaling Pathways and Interactions
paper · doi:10.1126/science.1071924
openalex publication_date 2002/05/31 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/04
Tumor necrosis factor (TNF) is a major mediator of apoptosis as well as inflammation and immunity, and it has been implicated in the pathogenesis of a wide spectrum of human diseases, including sepsis, diabetes, cancer, osteoporosis, multiple sclerosis, rheumatoid arthritis, and inflammatory bowel diseases. The interaction of TNF with TNF receptor-1 (TNF-R1) activates several signal transduction pathways. A common feature of each pathway is the TNF-induced formation of a multiprotein signaling complex at the cell membrane. Over the past decade, many of the components and mechanisms of these signaling pathways have been elucidated. We provide an overview of current knowledge of TNF signaling and introduce an STKE Connections Map that depicts a canonical view of this process.