1998/11/01 by N. Scott Adzick, Leslie N. Sutton, Timothy M. Crombleholme +1 · 5 citations
Medicine · Psychology · #Anencephaly #Biology #Congenital Anomalies and Fetal Surgery #Embryo #Fetal surgery #Fetus #Gestation #Grief, Bereavement, and Mental Health #Hydrocephalus #In utero #Medicine #Neural tube #Neural tube defect #Paraplegia #Pregnancy #Spina bifida #Spinal Dysraphism and Malformations #Spinal cord #Surgery
paper · pdf · doi:10.1016/s0140-6736(98)00070-1
openalex publication_date 1998/11/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
Spina bifida occurs in one of 2000 livebirths and leads to lifelong and devastating physical disabilities including paraplegia, hydrocephalus, incontinence, sexual dysfunction, skeletal deformations, and mental impairment.1 Compelling experimental evidence shows that the neurological deficit associated with open spina bifida is not entirely caused by the primary defect of neurulation, but rather is due to chronic mechanical injury and amniotic fluid-induced chemical trauma that progressively damages the exposed unprotected fetal neural tissue during gestation.