The trouble with antidepressants: why the evidence overplays benefits and underplays risks—an essay by John B Warren

2020/09/03 by J. B. Warren · 1 citation
Medicine · Neuroscience · #Treatment of Major Depression #Schizophrenia research and treatment #Pain Management and Placebo Effect

paper · doi:10.1136/bmj.m3200

openalex publication_date 2020/09/03 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30

Abstract

Widespread prescribing has not reduced mental disability or suicide, raising questions about the assessment of evidence on effectiveness and safety of antidepressants, writes <b>John Warren</b>

Citations

• Empirically derived criteria cast doubt on the clinical significance of antidepressant-placebo differences
• Can Long-Term Treatment With Antidepressant Drugs Worsen the Course of Depression?
• Selective Publication of Antidepressant Trials and Its Influence on Apparent Efficacy
• Comparative Efficacy and Acceptability of 21 Antidepressant Drugs for the Acute Treatment of Adults With Major Depressive Disorder: A Systematic Review and Network Meta-Analysis
• Should antidepressants be used for major depressive disorder?

Cited by

• Antidepressant [wikipedia]